Histidine Production by Auxotrophic Histidine Analog-resistant Mutants of Corynebacterium glutamicum
نویسندگان
چکیده
منابع مشابه
Histidine biosynthesis, its regulation and biotechnological application in Corynebacterium glutamicum
l-Histidine biosynthesis is an ancient metabolic pathway present in bacteria, archaea, lower eukaryotes, and plants. For decades l-histidine biosynthesis has been studied mainly in Escherichia coli and Salmonella typhimurium, revealing fundamental regulatory processes in bacteria. Furthermore, in the last 15 years this pathway has been also investigated intensively in the industrial amino acid-...
متن کاملMembrane Topology and Heme Binding of the Histidine Kinases HrrS and ChrS in Corynebacterium glutamicum
The HrrSA and the ChrSA two-component systems play a central role in the coordination of heme homeostasis in the Gram-positive soil bacterium Corynebacterium glutamicum and the prominent pathogen Corynebacterium diphtheriae, both members of the Corynebacteriaceae. In this study, we have performed a comparative analysis of the membrane topology and heme-binding characteristics of the histidine k...
متن کاملDevelopment of biotin prototrophic and hyper - auxotrophic 2 Corynebacterium glutamicum strains toward biotin production
1 Development of biotin prototrophic and hyper-auxotrophic 2 Corynebacterium glutamicum strains toward biotin production 3 4 Running title: Engineering of C. glutamicum biotin auxotrophy 5 6 Masato Ikeda,* Aya Miyamoto, Sumire Mutoh, Yuko Kitano, a Mei Tajima, a Daisuke 7 Shirakura, Manami Takasaki, Satoshi Mitsuhashi, and Seiki Takeno 8 9 Department of Bioscience and Biotechnology, Faculty of ...
متن کاملHistidine regulatory mutants in Salmonella typhimurium II. Histidine regulatory mutants having altered histidyl-tRNA synthetase.
(1) The hid’ gene of Salmonelb ty(phinzurium is the structural gene for histidyltRNA synthetase. Mutants in the hid gene have an altered histidyl-tRNA synthetase and constitute one of the four classes of histidine regulatory mutants. (2) Mutant hisS1520 has a synthetase with a 60.fold decreased affinity for histidine. This mutant has a markedly decreased growth rate on minimal medium and is de-...
متن کاملFermentative Production of Lysine by Corynebacterium glutamicum from Different Carbon Sources
Production of lysine by Corynebacterium glutamicum (PTCC 1532) from different agricultural by-products (molasses and pulpy waste date) was compared to glucose as raw materials. For this purpose, ammonium sulphate was selected as a constant nitrogen source. The effect of different nitrogen sources was also investigated with glucose as a constant carbon source. The production of L-lysine was exam...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1974
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.38.189